In May 2019, College Board published the first national operational SAT® validity study on the new SAT introduced in 2016. Based on data from more than 221,000 students across 169 four-year colleges and universities, the study showed that the SAT was essentially as effective as high school grades in predicting students' college performance and that these two measures, when combined, offer a more accurate understanding of student performance than either measure used alone. The current study extends the College Board's validity research on the new SAT. Using data from 221,300 students enrolled at 169 four-year colleges and universities, we examined relationships between SAT section scores, test scores, cross-test scores, and subscores with domain-specific course grades earned in college. Results of this study show a strong, positive relationship between SAT scores and grades in matching college course domains, suggesting that the SAT is sensitive to instruction in English language arts, math, science, and history/social studies. On their own and combined with high school GPA (HSGPA), SAT scores provide valuable information for colleges and universities as they make admission and course placement decisions. These scores also allow institutions to identify students who can benefit from additional academic support as they enter college and can inform important conversations with students about course selection and choice of major based on students' academic strengths and weaknesses.