As sensors and computers become smaller and smaller, it becomes possible to add intelligence or smartness to common items. This is already seen in smart appliances, cars that diagnose their own maintenance problems, and military hardware that is something straight out of a science fiction book. In this article, the author looks at a design challenge concerning smart clothing for a number of applications, i.e., construction workers, scuba divers, firefighters, astronauts, pregnant women, and gymnasts.