The objective of this study is to reveal the effect of the use of smart board in the biology class at the tenth grade of the secondary education on the academic achievements of students. The study used the quasi-experimental model with pre-test and post-test control groups and semi-structured interviews were made with the students. The study group of the research consists of the 50 students at the tenth grade in an Anatolian High School in the Buca District of the Izmir province. The lessons with the students in the test group included the contents which were prepared by the methods and techniques based on the constructive learning approach and taught by using the smart board. The students in the control group were instructed with the activities that were specified in the current curriculum. As a result of the study, a significant difference was found between the achievements of the test group and control group students. The achievement of the test group students was found to be higher than the control group students. In addition, the interviews with the test group students provided comprehensive opinions on the use of smart boards.