Objective: To examine the prevalence and trend of inhalant use among Indiana public school students. Methods: The Alcohol, Tobacco, and Other Drug Use among Indiana Children and Adolescents surveys conducted annually between 1991 and 2004 were reanalyzed using 2-way moving average, Poisson regression, and ANOVA tests. Results: The prevalence had increased during 1991-1997, decreased during 1997-2002, and increased again since 2003. Poisson model estimated an average annual decrease rate of 5.6%. The intensity of inhalant use had also decreased. More males and Hispanics use inhalants. Conclusion: Inhalant use needs to be addressed in drug prevention programs.