ERIC Number: EJ843097
Record Type: Journal
Publication Date: 2009-Jun
Abstractor: As Provided
Exchange Protein Activated by cAMP Enhances Long-Term Memory Formation Independent of Protein Kinase A
Ma, Nan; Abel, Ted; Hernandez, Pepe J.
Learning & Memory, v16 n6 p367-370 Jun 2009
It is well established that cAMP signaling within neurons plays a major role in the formation of long-term memories--signaling thought to proceed through protein kinase A (PKA). However, here we show that exchange protein activated by cAMP (Epac) is able to enhance the formation of long-term memory in the hippocampus and appears to do so independent of PKA, thus demonstrating the importance of Epac-mediated signaling in memory consolidation.
Descriptors: Long Term Memory, Brain, Neurological Organization, Brain Hemisphere Functions, Cognitive Processes
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Publication Type: Journal Articles; Reports - Descriptive
Education Level: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A