The Voice-Interactive Depression Assessment System (VIDAS) is a computerized speech recognition application for screening depression based on the Center for Epidemiological Studies--Depression scale in English and Spanish. Study 1 included 50 English and 47 Spanish speakers. Study 2 involved 108 English and 109 Spanish speakers. Participants completed demographic and acculturation scales, Beck Depression Inventory--II, Beck Anxiety Inventory, Composite International Diagnostic Interview--Short Form, and VIDAS (aural or visual). Both studies examined the psychometric properties and participant comfort ratings for VIDAS. Study 2 also examined psychometric sensitivity and specificity, and participant selection of digitized gender for VIDAS. Both studies found that VIDAS generally demonstrated adequate interitem reliability, convergent validity, sensitivity, and specificity. However, the aural modality displayed lower reliability and validity. Participants in both language groups rated each VIDAS modality favorably; however, the visual modality received higher positive evaluations. Participant comfort ratings of digitized gender revealed an interaction, such that the visual female and the aural male were rated more favorably. (Contains 2 tables and 1 figure.) [Minority Biomedical Research Support (MBRS) grant number MS4567 from the National Institute of General Medical Science and a Loan Repayment Program (LRP) grant from the National Institutes of Health National Center for Minority Health and Health Disparities supported the development of this manuscript.]