In this article, the authors share the case of John, a college freshman who had been struggling with depression. To work around John's case, the authors conducted an interview with John's parents. Based on the interview, it is found out that John's depression was largely caused by his relationship with his parents and the environment at their home. It is also revealed that there was a history of depression in John's family. Recommendations for treatment and a discussion of prognosis is also presented in this article. [ For Part I, see EJ754676. For Part II, see EJ754679.]