Approximately one-third of children with autism spectrum disorder (ASD) reportedly lose skills within the first 3 years, yet a causal mechanism remains elusive. Considering evidence of strong genetic effects for ASD and findings that distinct phenotypes in ASD associate with specific genetic events, we examined rates of parent-reported regression…

Interest in the study of gene-environment interaction has recently grown due to the sudden availability of molecular genetic data--in particular, polygenic scores--in many long-running longitudinal studies. Identifying and estimating statistical interactions comes with several analytic and inferential challenges; these challenges are heightened…

Biology is a data-driven discipline facilitated greatly by computer programming skills. This article describes an introductory experiential programming activity that can be integrated into distance learning environments. Students are asked to develop their own Python programs to identify the nature of alleles linked to disease. This activity…

Due to its distinct phenotype and relatively simple inheritance pattern, the phenylthiocarbamide (PTC) loci is frequently utilized in teaching laboratories to demonstrate genetic concepts such as Mendelian inheritance and population genetics. We have developed a next-generation sequencing and bioinformatics approach to analyze the PTC gene locus…

One crucial characteristic of scientifically literate individuals is making informed decisions in socioscientific issues (SSI). Participants' reasoning patterns and their risk perceptions shape their decisions. Thus, determining participants' informal reasoning patterns along with their risk perceptions while making decisions in SSI becomes…

This article examined the success of broadly defined family engagement activities of Latinx parents of students at Gene Ward Elementary School. Gene Ward Elementary School is a part of the Clark County School District in Las Vegas, Nevada. This article is based on a larger study of parent and family member participants in these activities at 25…

Bioethics is an important aspect of understanding the relationship between science and society, but studies have not yet examined undergraduate student experiences and comfort in bioethics courses. In this study, we investigated undergraduate bioethics students' support of and comfort when learning three controversial bioethics topics: gene…

School genetics is changing. Nowadays, students are more likely to be introduced to the idea that many characteristics of organisms, including those of humans, are not determined by the actions of just one or two genes but result from interactions between the products of many genes and the environments of each organism. This article asks whether…

"ATRX" mutations are commonly associated with alpha-thalassaemia mental retardation syndrome (ATR-X syndrome) with a notable variable expressivity. This X-linked disorder is characterized by intellectual disability (ID) in a higher or lesser degree, in which the alpha-thalassaemia feature is not always present. Other phenotypic…

Gene transcription is a crucial step in the sequence of molecular, synaptic, cellular, and systems mechanisms underlying learning and memory. Here, we review the experimental evidence demonstrating that alterations in the levels and functionality of the methylated DNA-binding transcriptional regulator MeCP2 are implicated in the learning and…

In conjunction with the 30th anniversary of the open access scholarly journal, "Education Policy Analysis Archives," Founder and Editor Emeritus Gene V Glass presents a brief history of the journal, including its online predecessors and offshoots, within the context of computer and information technology developments and the early open…

Animal models are widely used in laboratory practicals in biomedical disciplines. However, experiments involving animal work are usually time-and-labor consuming. It is also costly to run an animal lab and the animal caring/holding request special training. Here we present a laboratory course design that provides students with wet lab experience…

This dissertation aimed to advance the field of biology education in several ways. First, we aimed to demonstrate if, and to what extent, student-generated conceptual models can be used on summative assessments to accurately assess student understanding of gene expression. Next, we described patterns of changes students make to conceptual models…

The past fifteen years has seen a dramatic improvement in our understanding of hearing and hearing loss. Scientists have worked to identify dozens of genes involved in hearing loss and elucidate the complex molecular machinery responsible for hearing. At the same time, there have been rapid advances in clinical diagnostic tools including imaging…

Fragile X syndrome (FXS) has a classic phenotype, however its expression can be variable among full mutation males. This is secondary to variable methylation mosaicisms and the number of CGG triplet repeats in the non-coding region of the Fragile X Mental Retardation 1 ("FMR1") gene, producing a variable expression of the Fragile X…