Objective: A systematic evaluation of the effectiveness of culturally sensitive interventions (CSIs) with Native American youth was conducted. Method: Electronic bibliographic databases, Web sites, and manual searches were used to identify 11 outcome studies that examined CSI effectiveness with Native American youth. Results: This review found general improvement in the employment of rigorous evaluative methods in CSI research with Native American youth. Conclusion: Despite recent progress, CSI research remains in its infancy and more rigorous outcome studies are needed in order to determine if CSIs are more effective than standard treatments with Native American youth. Such research is necessary for professional competent practice with Native American youth and families. (Contains 1 table.)