Objective: The purpose of this "phronetic," qualitative study was to examine exercise facilitators and barriers among Native American freshmen in relation to life challenges during their transition from high school to college. Participants: Seven Native American freshmen college students (females = 2, males = 5) were recruited. Methods: A focus group and individual interviews on exercise values and life challenges were conducted. Results: Based on the thematic analysis, three themes emerged, including several sub-themes. Factors affecting transition to college (theme 1) included: a) being independent and responsible and b) supportive environment. Exercise barriers (theme 2) included: a) lack of time, b) exercise options and level of competition, and c) limited equipment and exercise partners. Exercise facilitators (theme 3) included: a) Native American traditional activities and b) social multi-cultural opportunities. Conclusion: Exercise promoters should take into consideration the Native American culture and networks for Native American freshmen.