In facilities throughout the United States and abroad, communities of scientists share infrastructure, instrumentation, and equipment to conduct scientific research. In these large facilities--laboratories, accelerators, telescope arrays, and research vessels--scientists are researching key questions that have the potential to make a significant impact on a broad segment of a scientific or engineering discipline. In most of these large facilities, there is also an effort being made to share--through education, outreach, and other public communications activities--the science research being explored at these labs and to contribute within the science education arena. Just as the facilities themselves are intended to be infrastructure for science, the education and outreach activities associated with these facilities are regional infrastructure for science education. One such scientific facility is the Sanford Underground Research Facility. For the past five years, the education and outreach effort of Sanford Lab has been supported by a grant from the National Science Foundation to plan, develop, prototype, and prioritize the suite of educational activities of the lab. Now known as the Sanford Science Education Center (SSEC), education and outreach activities that showcase the science, engineering, and technology of Sanford Lab are offered in partnership with the Sanford Lab Homestake Visitor Center and Black Hills State University. This case study shares the design challenges the SSEC has faced (and where appropriate, drawing on other examples as well), and the lessons learned from trying to meet these design challenges. The audiences for this case study are those in the broader field of education, outreach, and public communication of science; and federal agencies who fund these efforts, such as the National Science Foundation and the Department of Energy.