This article reports the results of a meta-analysis of the effectiveness of 7E learning cycle in science teaching. Totally 35 different effect sizes from 24 experimental studies, comprising 2918 students were included in the meta-analysis. The results confirmed that 7E learning cycle have a positive effect on students' achievement. The overall effect size (Hedges's g) value obtained from independent studies was calculated as 1.245 (% 95 CI, SE = 0.148) between confidence intervals 956 and 1.534 according to the random effects model. Among all effect sizes 32 had a positive effect whereas 3 of them had negative effect. A number of sub-group analyses (school level, type of publication, subject matter and duration) were conducted. The effect of 7E was not significant for school level, type of publication and duration. However, regarding the subject matter a significant difference was observed. The high effect size calculated in this meta-analysis implies that the 7E learning cycle is a useful strategy that should be included in science curriculums.