The purpose of this research is to determine whether there is a meaningful relationship between secondary school students' attitude and perception levels of self-efficacy oriented by research-inquiry and as well whether students' attitude and self-efficacy levels differ according to grade and gender. The working group of the study consist of 234 secondary school students. The descriptive model of one of the quantitative research methods was used in this research. The data of the study was collected with Perception Scale of Self-Efficacy Oriented by Research-Inquiry and Attitude Scale Oriented by Research-Inquiry. Percentages, mean, ANOVA, Schieffe and t tests have been benefited in this study. According to data obtained from the study, it has been concluded that students' attitude and self-efficacy levels oriented by research-inquiry were in a high level, it hasn't differed according to gender, there was a significant difference against the 8th Grade students between Grade 8 and Grade 5 and 7 regarding to the attitude level, there was a significant difference against the 8th Grade students between Grade 8 and Grade 6 and 7 regarding to self efficacy level, there was a positive and meaningful relationship between the levels of attitude and self-efficacy at a high level.