For decades, Latino English language learners (ELLs) have been identified as a high-risk population for both reading and behavioral problems. A comprehensive approach that provides academic and behavioral support in both home and school settings has been suggested by researchers as a viable option for improving outcomes of students who exhibit problems in both areas. Research has also suggested that cultural adaptations need to be implemented when working with culturally and linguistically diverse (CLD) populations to ensure cultural fit between the target population and the implemented interventions. This paper presents the results of a pilot study that examined the effects of a comprehensive, culturally adapted intervention on Latino ELLs behavior and reading skills. A multiple-baseline, single-subject research design was employed in this study. The results suggest that implementing a comprehensive and culturally adapted intervention has promising effects among Latino students and families. Participating students demonstrated decreases in problem behaviors and low-moderate increases in reading skills. Implications for research and practice are discussed.