"iMOOC101: Mastering American e-Learning" is a Coursera-based, free, massive online course aimed at preparing non-U.S. students to succeed in regular, for-credit, online classes in American universities. The course is also intended to help foreign-born professionals integrate into virtual work environments in U.S.-based companies. The development of the course is informed by two decades of practical experience of one U.S. public university in the field of international distance learning. The course is designed as a virtual laboratory of culture shock (Chukhlomin, 2010, 2016) where students are exposed to unfamiliar virtual environments and learn how to understand and adapt to the American online culture, the academic system, and professional contexts. The course had initially been developed as a small-scale, for-credit, online course; in 2014-2015 we obtained two Innovative Instructional Technology Grants to transform it into a MOOC format. Here we report on the design principles and the first results. [For the complete proceedings, see ED579282.]