"Generation Rx" is a prescription drug abuse prevention strategy which includes a "toolkit" designed to be used with youth. Developed by Cardinal Health Foundation and the Ohio State University, it provides health care providers (especially pharmacists), parents, teachers, youth workers, and other community leaders with interactive tools and resources aimed at educating teens about the realities and dangers of prescription drug abuse. This article highlights Generation Rx, showcases how two community-based programs have implemented components of the toolkit, and presents a preliminary assessment about its impact. (Contains 1 table.)