Utilizing ecological theory and multiple world theory, the current study investigated the effects of cultural factors (i.e., Familismo and school climate), parental involvement, and academic socialization on academic achievement of Latina/o secondary school students. This study had 2 primary foci. First, this study sought to address how the cultural value of Familismo and the interaction between home and school cultures play a role in parental involvement and academic achievement. Second, the effect of academic socialization was tested as a distinct factor from parental involvement. Data were collected from 116 Latina/o students living along the U.S./Mexico border. This study tested a path model that explained 30% of the variance in academic achievement, 25% of the variance in academic socialization, and 21% of the variance in parental involvement. Among 8 proposed relationships, 6 were supported while 2 were not. The mediating effects of parental involvement and academic socialization were supported that connect Familismo, school climate, and academic achievement. Implications for Latina/o secondary students who navigate between the different cultural worlds of home and school are discussed.