Aggressive immigration enforcement hurts the very youngest children. Refugee and U.S.-born children of undocumented immigrants experience many childhood adversities, compromising their development and health. Refugee children flee traumatizing violence in their home countries, face grueling migrations, and are harmed further by being held in detention centers. Citizen-children of undocumented immigrants fret every day that their parent will not come home because they were apprehended, detained, or deported. They become hypervigilant, anxious, and depressed from constant worry. When parents are deported, citizen-children become orphans or exiles. This article discusses the situations of these youngest refugees and citizen-children and how threats of detention and deportation affect them.