Research on Asian Americans and their psychological adjustment is limited. Consisting of two cross-sectional studies, the present investigation examined the relationships among self-concealment, mindfulness, emotional distress in stressful interpersonal situations, and general psychological ill-health in Asian American college students, and in comparison with European American counterparts. In the Asian Americans, self-concealment was found to be positively related to general psychological ill-health and negatively related to mindfulness. In both ethnic groups, mindfulness was found to be negatively related to general psychological ill-health. Findings suggest that, as seen with European American counterparts, both self-concealment and mindfulness may be important concepts in understanding the psychological adjustments of Asian American college students.