The connections between the design and use of space in higher education, and the production of teaching and learning, and of research, are not well understood. This paper reports on a literature review on these topics, and shows that higher education spaces can be considered in various ways: in terms of campus design, in terms of how space can support the development of a university community, the needs of specialist spaces, and the impact of technology on space use. Space issues are central to the operation of universities, and further research is needed to illuminate the connections between space and institutional effectiveness.