The current study examines if participants completing an early online academic orientation display significantly higher levels of achievement in anatomy and physiology (A&P) compared to those who do not complete this orientation. The study involves a sample of first year nursing students in a private Catholic college in a major midwestern city in the United States. A bivariate model indicates that success in A&P is significantly associated with composite test of essential academic skills scores (TEAS scores) and composite ACT scores. The bivariate model reflects those students who attend an early online academic orientation have significantly higher levels of achievement in an A&P course relative to those that do not. Future research may benefit from a mixed-methods design that might include a qualitative piece incorporating student perspectives regarding why attending an early academic orientation might be associated with higher achievement outcomes in A&P relative to those who do not attend such an orientation.