Mental health and attainment gaps comprise crises on university campuses, especially for first-generation and low-income students. Despite the heritage of spirituality and religious foundations of America's colleges, current norms have rendered candid discussions of spirituality to be mostly nonexistent. Despite literature linking spirituality with psychological wellbeing, known is little as to what relationship spirituality has with psychological wellbeing and academic performance, particularly among first-generation and low-income students. This study uses a cross-sectional survey design and occurred a public, regional, Midwestern institution. Quantitative analysis found a relationship between psychological wellbeing and academic performance in specific circumstances, and an indirect effect between spirituality and academic performance in the presence of psychological wellbeing. These data presents implications for practitioners.