This study aims to assess the relationship between crash outcomes and the knowledge of mobile phone hazards, attitude towards mobile phone use, and practices of mobile phone use among urban Nigerian drivers. The study used a quantitative cross-sectional analytical design. A total of 377 completed responses were obtained through a self-administered questionnaire. The outcome measures were self-reported crash involvement, self-reported crash injury, and self-reported mobile phonerelated crash involvement. The main predictor variables were the knowledge of mobile phone hazards while driving, attitude towards mobile phone use while driving, and practices of phone use while driving. Age, sex, marital status, level of education, and driving experience were used as potential confounders. Univariate and multivariate logistic regression analyses were used to compute the unadjusted and adjusted odds of each crash outcome. The results show almost 75% of the study population reported that they had been involved in a crash event and sustained crash injuries in the past. Drivers with poor knowledge of mobile phone hazards while driving had significantly elevated odds of self-reported crash outcomes compared to those with good knowledge of mobile phone hazards while driving. Similarly, poor attitude towards phone use while driving and bad practice of phone use while driving were associated with significantly elevated odds of self-reported crash outcomes. The conclusion calls for a need for greater awareness and intervention aimed at improving knowledge, influencing attitude, and changing the practices around mobile phone use among Nigerian drivers.