Purpose: This research aimed to examine the usefulness of a microbiology digital handout as a teaching material validated by experimental research in the improvement of science process skills and cognitive learning outcome of students. Methodology: The study comprises two methods: experimental research and development research. The experimental research at Microbiology laboratory of Faculty of Mathematics and Natural Science State University of Malang, while the development of teaching material in the Department of Agricultural Industrial Technology, Faculty of Agriculture, UNITRI Malang. A digital learning model was devised with ADDIE approach and implemented along with PBL model on experimental and control groups. Findings: Findings revealed that the improvement in student's science process skills and cognitive learning outcome in the experimental class was higher than those in the control class. Implications for Research and Practice: Learning by using a digital handout could increase students' activities and achievements, particularly in scientific learning. It would be very useful to solve the problems that might be encountered in the daily life. It could trigger the curiosity of students to examine and observe more on problems in the real life.