Previous research has shown that the well-being of people in Western societies varies consistently. To understand these differences, we focus on the relationship between healthcare use and well-being, since previous research has shown that poor health and lack of social support reduce well-being. Based on the findings of the previous research, we hypothesize that there is a positive relationship between healthcare use and well-being, and that the strength of this relationship increases with the years of schooling. We tested these hypotheses in 24 countries using data (N = 40,249) from the European Social Survey. The data were analyzed using hierarchical multiple regression models. Our results indicate cross-national differences in the relationship between healthcare use for serious health problems and well-being. Moreover, they suggest that the extent of education matters for this relationship, however its influence differs across countries. Further research is needed to explain these cross-national differences.