The purpose of this study was to explore the experience and management of stress in science students and to evaluate concordance with faculty/staff members' appraisal of student stress. A survey was completed by 308 students and by 40 staff and faculty members. Students' stress levels were high but there were no differences based on demographic groups. Students' top stressors included workload, grades, career, time management, and anxiety. Faculty and staff members accurately estimated the level of undergraduate student stress but underestimated graduate student stress. They also demonstrated a good understanding of the role of specific academic stressors, but consistently overestimated the contribution of stress from other sources. Students described using a variety of different coping strategies, including social support, self-care, hobbies, and problem-solving.