It is hypothesized that creating case studies that are visually and kinesthetically interactive will encourage experiential and active learning, as well as enhance student engagement and a sense of enjoyment in learning. The case studies in this study were designed to incorporate reading, visual imagery, as well as auditory and hands-on activities for the students. Specifically, each question created has an experiential and/or active component as well as immediate electronic auto-feedback. It was expected that students would find the incorporated images, video clips, interactive websites, as well as hands-on plastic models appealing as well as helpful in their learning. Additionally, it was anticipated that the case studies would assist with remembering key aspects of pathophysiology for the final exam. The four case study topics focus on peptic ulcers, cardiovascular diseases, diabetes, and bone fractures coupled with osteoporosis and sciatica. In addition, each case study begins with reflective questions that are designed to add a metacognitive component to each lesson. Surveys were given after each case study to gauge student satisfaction. In addition, final exam questions responses were analyzed for signs of improvement.