The present study investigated the identification of end of first grade (n = 125) and end of third grade (n = 77) reading comprehension difficulties using beginning of first grade decoding-related and language-related predictors. Reading comprehension was defined using a composite of three standardized reading comprehension measures. Students at or below the 25th percentile on the reading comprehension composite were considered to have difficulty with reading comprehension. Sight word reading efficiency and sentence repetition predicted end of first grade reading comprehension difficulties. Sight word reading efficiency, sentence repetition, and oral discourse predicted end of third grade reading comprehension difficulties. Both screening batteries yielded high classification accuracy (area under the receiver operating characteristic curve [AUC] = 94.7% in Grade 1 and AUC = 90.5% in Grade 3). Results are discussed in light of the research base on early screening for reading comprehension difficulties.