Research has found that adolescents who report being gay, lesbian, or bisexual (i.e., sexual minorities) are at higher risks for using alcohol, tobacco, and other drugs (ATOD). Although there are numerous studies that have identified health disparities among sexual minority youth as a whole, few have assessed whether teens who report bisexuality are at a higher risk for ATOD use. As such, the purpose of this study was to assess the relationship of bisexuality and ATOD use among high school students. Data for this study were derived from the 2015 Youth Risk Behavior Study (YRBS). A total of 15,624 participants completed the YRBS in 2015 with 6.6% being bisexuals. The results of this study found that students who reported bisexuality were significantly more likely to report ever use and current use of cigarettes and alcohol. Bisexuals were also significantly more likely to binge drink (OR= 2.69) and ever use inhalants (OR= 2.17. Our results add to the literature that seeks to understand behaviors specifically impacting individuals identifying as bisexual. More research is needed to better understand the factors that may contribute to such behavioral differences between bisexual- and heterosexual-identified teens.