This Statistics Report is the second in a new series produced by the Research Division at Cambridge University Press and Assessment, using publicly available school performance data from the Department for Education (DfE). This report is focused on the uptake of General Certificate of Secondary Education (GCSE) subjects in England in 2019. The data were downloaded from the DfE's 'Find and compare schools in England' service, and consisted of Key Stage 4 (KS4) results at a school level in all subjects in schools and colleges in England, as well as school characteristics such as school gender, admissions policy, and the number of disadvantaged pupils at the end of KS4. GCSE uptake is defined as the percentage of students at the end of KS4 taking a GCSE subject. The following qualifications were counted for this report: GCSE Full Course, GCSE (9-1) Full Course, GCSE (9-1) Full Course (Science Double Award). GCSE uptake was analysed by different school classifications: school type, attainment group, school gender and deprivation level. In the tables in this report, the numbers of students in each of the classifications are presented. [For the 2018 report, see ED621953.]