Approximately half of all children under the age of three in the United States have a regular child care arrangement (nearly 44 percent of infants from birth to 12 months, 52 percent from 12 to 24 months, and 56 percent from 24 to 36 months; NSECE Project Team, 2015). The percentages of infants and toddlers in center-based care increases with age, with nearly nine percent of infants from birth to 12 months, thirteen percent of infants from 12 to 24 months, and twenty percent of toddlers 24 to 36 months of age in center-based care (NSECE Project Team, 2015). Research suggests high-quality care and learning programs that begin early in life have the potential to improve developmental outcomes as well as close gaps in educational achievement for young children (Mayoral, 2013; NICHD, 2005; Yazejian, Bryant, Freel, Burchinal, & the Educare Learning Network Investigative Team, 2015). However, observed quality in infant and toddler settings is low in general (Phillips & Lowenstein, 2011; Vogel et al., 2011) and often lower than in preschool settings (NICHD, 2005). This brief focuses on implementation and standards in center-based settings because family child care homes are already structured to support relationship-based care practices from infancy through age three due to small numbers of children and caregivers. However, considerations for implementation of relationship-based care practices in centers may also be relevant to group child care homes serving infants and toddlers. [This brief was developed as a collaboration between members of the Network of Infant/ Toddler Researchers (NITR) and the Quality Initiatives Research and Evaluation Consortium (INQUIRE).]