In this companion to the "NASA SCI Files" episode "The Case of the Great Space Exploration," the tree house detectives learn about NASA's new vision for exploring space. In four segments aimed at grades 3-5, students learn about a variety of aspects of space exploration. Each segment of the guide includes an overview, a set of objectives, vocabulary to be learned, a video component, related careers, resources, and student activities and worksheets. Guide includes a table indicating how each segment meets national standards for science, mathematics, and technology literacy. [Additional funding for this lesson guide was provided by Busch Gardens, Williamsburg and the NASA Langley Research Center's Aerospace Vehicle Systems Technology Program Office.]