This guide aims to document the resources available to educators who work with struggling secondary readers--readers who struggle in general education and reading classes, grades 6 through 12. With the goal of building a guide to resources, the scholarly literature was reviewed to determine: (1) current theoretical perspectives and research findings on building reading proficiency at the secondary level; and (2) their implications for classroom instruction. Rather than reporting all the factors that can impact secondary-level reading proficiency, the guide presents factors for which a research base establishes essential importance and for which there are pedagogical implications. It identifies and describes programs and strategies that aligned with those findings. The guide is divided into the following parts: Introduction: (How To Use the Guide; How Resources Were Selected); Part 1: Perspectives (Struggling Secondary Readers: A Closer Look; Informal Assessment; Building Reading Proficiency at the Secondary Level; Principles of Effective Reading Instruction; Principles of Effective Professional Development); Part 2: Resources (Five Questions Organize the Programs and Strategies; Programs; Strategies; Definitions of Terms); and Part 3: Procedures for Compiling the Guide. (Contains a 164-item bibliography.) (NKA)