Two word-spotting experiments were conducted to examine the question of whether native Cantonese listeners are constrained by phonotactics information in spoken word recognition of Chinese words in speech. Because no legal consonant clusters occurred within an individual Chinese word, this kind of categorical phonotactics information of Chinese word may be most likely to cue native Cantonese listeners the locations of possible word boundaries in speech. The observed results from the two word-spotting experiments confirmed this prediction. Together with other relevant studies, we suggest that phonotactics constraint is one of the useful sources of information in spoken word recognition processes of Chinese words in speech.