Given the importance of both academic and self-determination skills for students with disabilities, it is important to identify efficient ways to deliver instruction in these essential areas. This literature review synthesizes intervention research that has examined the effects of self-determination interventions on academic skills for students with learning disabilities (LD) and/or attention deficit/hyperactivity disorder (ADHD). Our findings revealed that self-management interventions were most often studied, followed by interventions that combined self-management with one or more other self-determination components. Effects ranged from very weak to very strong. Effects were strongest when (a) interventions that combined self-management with goal setting were used to increase students' productivity, and (b) goal-setting interventions were used to improve math skills. Most of the studies included in the review were of high quality; however, some areas could be improved. (Contains 3 tables.)