ERIC Number: EJ892456
Record Type: Journal
Publication Date: 2010
Pages: 13
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-1931-5864
EISSN: N/A
Long-Term Safety and Adverse Events of Risperidone in Children, Adolescents, and Adults with Pervasive Developmental Disorders
Hellings, Jessica A.; Cardona, Alicia M.; Schroeder, Stephen R.
Journal of Mental Health Research in Intellectual Disabilities, v3 n3 p132-144 2010
The objective of this study was to examine long-term adverse events of risperidone in 19 children, adolescents, and adults with Pervasive Developmental Disorders and intellectual disability, continuing risperidone for a mean of 186.5 weeks, following a 46-week risperidone study. Nineteen individuals continued long-term follow-up after our published risperidone placebo-crossover acute study (22 weeks) and 24-week maintenance phase on 40 participants. Long-term ratings included the Dyskinesia Identification Systems Condensed User Scale and Neuroleptic Side Effects Checklist. Weight and prolactin levels were also measured. A range of significant neurological side effects occurred: akathisia in 10%, 2 individuals developed tardive dyskinesia, 1 developed oculogyric crisis; withdrawal dyskinesia occurred in 2 of 9 individuals discontinuing risperidone. All 10 children and adolescents continued greater than 7% weight gain. Adults gained less weight, but 2 developed Type 2 diabetes. Prolactin (PRL) elevation continued in all 7 patients with PRL measures but normalized in 2 individuals after aripiprazole addition. Movement side effects were significant. Children and adolescents continued greater than 7% weight gain; PRL elevation continued. (Contains 3 tables.)
Descriptors: Mental Retardation, Pervasive Developmental Disorders, Drug Therapy, Safety, Child Health, Symptoms (Individual Disorders), Children, Adolescents, Adults, Check Lists, Neurological Impairments, Age Differences, Diseases, Body Weight, Attention Deficit Hyperactivity Disorder, Mental Disorders
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A