This paper describes a matrix for clinical use in the selection of phonological treatment targets to induce generalization, and in the identification of probe sounds to monitor during the course of intervention. The matrix appeals to a set of factors that have been shown to promote phonological generalization in the research literature, including the nature of error patterns, implicational universals, developmental norms, and stimulability. A case study of a child with a phonological disorder is presented to illustrate how the matrix may be utilized in evidence-based practice. The matrix serves as a demonstration of how the translation of research to practice may be accomplished. (Contains 2 tables and 2 figures.)