At present, there is limited evidence supporting the effectiveness of family-based intervention programs to prevent violence or related behavior problems with Latino youth and families. Although progress has been made, a number of important issues remain. In this article, the authors review several of the more prominent interventions for Latino youth and families, highlighting how they were adapted to or developed for Latino culture. They begin by discussing cultural sensitivity and how it affects the design, implementation, and adaptation of youth violence prevention programs. Following this, the authors review and discuss programs adapted for Latino families followed by programs developed specifically for Latino families. They highlight four primary components of family-based programs that have been linked most frequently to prevention outcomes: (a) improving parental monitoring, (b) increasing family cohesion, (c) increasing networking across families, and (d) empowering families to access resources more effectively. (Contains 2 tables.)