South African teachers are faced with challenges in integrating technology effectively into a coherent framework at school level. There seems to be little evidence of technology integration into classroom activities such as systematic planning and implementation of lessons that require learners to think critically, work collaboratively, and use technology in support of learning. A study was undertaken to investigate the challenges faced by senior secondary school teachers and learners in integrating technology effectively into teaching and learning activities. In-depth and group interviews were conducted with curriculum specialists, teachers and learners. Observations and document review were also used to collect qualitative data. Qualitative data analysis strategies were used to analyse data. The findings revealed unavailable technology policy, insufficient technology equipment, a lack of teachers qualified in technology integration, and maintenance and technical problems as the major challenges affecting the effective integration of technology at school level. Integrating technology effectively requires planning, sufficient time, dedication and enough resources.