The TPACK model is an essential framework for appropriately integrating technology in the classroom. The present study aimed to categorize and establish the main research findings around TPACK between 2017 and 2022, specifically in practicing teachers at the secondary education level. A systematic literature review guided by the PRISMA statement was conducted. The search for papers was carried out in the Scopus, Web of Science, Sage Journal, and SciELO databases in September 2022. 37 articles were selected for review. The review of the studies made it possible to establish that the papers were mainly grouped into two categories: the first related to teachers' perception of TPACK, which includes research with self-perception questionnaires, case studies and relationships of self-perception with other variables such as barriers to technology integration in the classroom, pedagogical beliefs, and online education; and the second to developing training courses based on TPACK, complemented with self-perception questionnaires in the form of pretest-posts, classroom observations, and interviews. The results of the first category are dissimilar since TPACK levels differ from one study to another in variables such as gender and teaching experience. From the second, it is established that teacher professional development courses favor improving technological integration in the classroom.