This study examined the effects of explicit instruction in the SOLVE Strategy on the mathematical problem solving skills of six Grade 8 students with specific learning disabilities. The SOLVE Strategy is an explicit instruction, mnemonic-based learning strategy designed to help students in solving mathematical word problems. Using a multiple probe across participants design, results suggested a functional relation between explicit instruction in the SOLVE strategy and increase in strategy use and computation scores on grade level mathematical word problems for all participants. Additionally, all participants generalized the SOLVE Strategy to other mathematic topics and concepts, and the teacher and students felt the intervention was socially acceptable. Finally, limitations, implications for practice, and suggestions for future research are discussed.