It is suggested that the value of projected cuts in UK higher education spending should be redirected to fund start-up entrepreneurial universities as part of a strategy for knowledge-based economic growth. Two specific elements of academic entrepreneurial redesign are outlined: the Professor of Practice, linking university and industry through half-time roles in each, and the Novum Trivium tripartite undergraduate degree, including a speciality subject, entrepreneurship education and a foreign language. A far-reaching response to resolve the economic crisis by hastening the foundation of university start-ups and their development into new clusters is envisioned. (Contains 4 notes.)