Team-based learning (TBL) is an instructional method that has been shown to reduce attrition and increase student learning in a number of disciplines. TBL was implemented in a first-semester general chemistry course, and its effect on attrition was assessed. Attrition from sections before implementing TBL (fall 2008 to fall 2009) was compared with that of sections after implementing TBL (spring 2010 to spring 2013). The attrition with TBL (19%) was found to be significantly lower than the attrition before implementing TBL (31%), z = 3.07, p = 0.002. These results offer the possibility, which remains to be tested, that TBL may provide a general solution of the problem of attrition in introductory science courses.