The association of overweight/obesity, and central obesity with thiocyanate (SCN), perchlorate (CIO), and nitrate (NO) in childhood and adolescence is unclear. Therefore, this study aimed to explore this association in 4447 participants comprising children and adolescents (aged 6-19 years) using data from the United States National Health and Nutrition Examination Survey 2005-2016. SCN level was positively associated with overweight/obesity in both children and adolescents, while CIO level was negatively associated with overweight/obesity only in children; however, no significant association was found for NO level. Similar associations were found between SCN level and central obesity. Thus, our results suggest that SCN exposure was associated with overweight/obesity and central obesity in both children and adolescents, while a negative association was observed for CIO in children. Strategies to monitor the exposure levels and the mechanisms underlying the relationship between exposure and the weight parameters are recommended.