The present study examines the sources of job stress in a national sample of 373 Greek special education teachers, using a self-report questionnaire assessing job stress, its perceived sources, and its demographic and professional characteristics. Although the participants in general considered their job moderately stressful, they felt stressed by issues concerning the special needs child, such as the child's progress, safety, and social development. More than half of the teachers indicated that teaching children with autism poses major stress to them, followed by teaching students with behavioural and emotional difficulties. Regression analysis showed that the implementation of the special educational curriculum was the most important predictor of job stress, followed by the social and academic progress of children. The implications of these findings for in-service and pre-service teacher preparation, support, and awareness-raising regarding job stress are discussed. (Contains 5 tables and 1 note.)