The history of science (HOS) has proven to be a useful pedagogical tool to help students learn about what has come to be regarded as an agreed upon set of core nature of science (NOS) tenets. The following article illustrates an example of how teachers can instrumentally use the history of research on heterozygote protection in sickle-cell anemia to help students learn tents of the NOS. The article concludes with a discussion of practical suggestions for interpreting other episodes from the HOS in a NOS framework.