The effects of religious attendance, religious importance, and gender on well-being, substance use, and academic engagement were examined among early adolescents (N = 683) from rural schools. Results indicated that females viewed religion as more important than males, although the frequency of religious attendance did not differ for males and females. Hierarchical regression results revealed that religious importance was a more prominent protective factor than attendance against substance use even after accounting for parental support; however, no links were found between religiosity and depression or self-esteem. Adolescents who reported that religion was important in their lives reported lower school misbehavior and higher motivation, although those with high religious attendance had higher grades. Interaction effects indicated that religious importance was particularly salient for males compared to females in terms of enhanced school bonding and self-efficacy. (Contains 3 tables and 2 figures.)