This article describes OSHA procedures for handling Occupational Exposure to Hazardous Chemicals in Laboratories. The Laboratory Standard requires a Chemical Hygiene Plan to address all aspects of working with hazardous chemicals. This includes dealing with chemical spills. Chemical spill kits or "spill crash carts" need to be available in case there is a spill incident in the laboratory. The first line of defense against a chemical spill is to try to prevent one from happening. An effective means of prevention is to provide active training and to use minimal amounts of hazardous chemicals. The micro-chemical approach has merit in terms of safety alone. Appropriate storage, use of containment devices, inspection of containers, and other things can again help keep the chances of a spill accident very low. However, as advocated by the National Science Education Standards, there should be virtually no use of hazardous chemicals in the middle level classroom.