The use of computers to facilitate learning is yet to make an appreciable in-road into the teaching-learning process in most developing Third World countries. The purchase cost and maintenance expenses of the equipment are the major inhibiting factors related to adoption of this high technology in these countries. This study investigated: (1) the attitude of students who operate within an indigenous technology-dominated environment toward the use of the computer in learning biological concepts; (2) whether an attitude change would result when such students engaged in the use of the computer on an individual or cooperative learning basis; and (3) whether students who operate within an indigenous technology-dominated environment achieve better in biology when learning is undertaken with the use of the computer. Achievement and affective data were collected from 64 students enrolled for a 3-month Nigerian Joint Matriculation Examination in Biology. Results indicated that the interactive use of the computer resulted in significant attitude change and significantly higher scores were obtained by the group that worked together cooperatively. The results also showed that the girls in the computer-assisted group had a significantly more positive attitude towards the use of the computer as a learning tool in biology than the boys. The educational implications of these results are discussed. (Author/CW)