Classroom tested ideas and resources for social studies and science teachers on toxic and hazardous substances are provided in this guide. Suggestions are included for ways of increasing student awareness and knowledge about this problem. Although the materials were primarily developed for junior high students they can be adapted and modified for other grade levels and can be integrated into an established curriculum framework. An introductory section provides an explanation on how to use the guide and also identifies potential problems and implications for instruction of this complex and controversial topic. Other sections contain: (1) 27 instructional activities (ranging from simulations and experiments to surveys and computer games); (2) annotated lists of audio-visual aids (with sources indicated); (3) a chart showing contributions of projects to meeting standards of learning (identifying the ways in which the instructional activities correspond to the State of Virginia's expectations in its Standards of Learning); (4) appendices (presenting major toxic substances laws, a guide for hazardous materials disposal, and lists of resource personnel and organizations); and (5) glossary (with definitions related to toxic and hazardous substances). (ML)